Life Sciences

Why Pharma Industry Needs to Take “China Plus One” Strategy Seriously 

By: Ankur Rishi

Key Takeaways

  1. Risk Mitigation: The China Plus One strategy reduces the risk of supply chain disruptions by diversifying suppliers across multiple countries, making the supply chain more adaptable to unexpected challenges.
  2. Cost Savings and Compliance: Rising labor costs in China and stringent compliance requirements make alternative countries like India attractive for manufacturing, offering cost savings and better compliance management.
  3. Market Access and Expertise: Diversifying manufacturing operations allows companies to tap into new markets and access specialized technologies and expertise in different regions, enhancing their competitive edge.
  4. Geopolitical Considerations: The shift towards China Plus One is driven by geopolitical tensions, trade conflicts, and the need to mitigate risks associated with overreliance on a single country, underscoring the importance of strategic diversification in global supply chains.

China continues as a manufacturing powerhouse, responsible for a third of all global output. However, the world’s manufacturing superpower might just be losing its steam after a dream run spanning more than four decades. A mix of factors is chipping away the country’s hard-built and seemingly unassailable credentials in production capacity and efficiency. Rising supply chain overheads, input cost inflations, tightening labor markets, and minimum wage hikes in the country are turning into potential dampeners for investors in the manufacturing sector, and industrial-scale pharma production is no exception.

Besides, the country’s growing focus on buttressing and expanding supply chains China, re-laying supply lines through allied states, and building a “fortress China” self-sustaining economy invariably conflicts with America’s own designs to rebuild supply chains closer to its shores. Enterprises, including bulk drug manufacturers, sit at the crossroads geopolitical tectonic plates, and there are valid concerns about cost and risk escalations arising from a commercial cold war. This is creating opportunistic circumstances for “China Plus One” country markets to step up and help MNCs, including pharma players, ringfence supply risks by expanding their supply footprint outside of China.

What is the China Plus One?

The China Plus One Strategy, sometimes referred to as Plus One or C+1, is a supply chain approach that promotes businesses to diversify the nations from which they obtain parts in order to reduce their reliance on China. This pattern is not brand-new. It has been developing for many years as a result of rising labour costs in China, trade tensions between the US and China, and stringent COVID-19 containment measures that force manufacturers to search outside of China. While labor-intensive production, like clothing assembly, has been relatively straightforward to relocate from China, the creation of sophisticated technology products, like smartphones, is expensive and creates major logistical obstacles. In spite of this, high-tech businesses are implementing these adjustments and erecting factories abroad to diversify their risks.

The five or so “China Plus One” economies, including India, have done their homework on the Chinese manufacturing model, liberally borrowing its strengths. At the same time, countries, like India, have the benefit of hindsight – which China didn’t have, to avoid the pitfalls of the Chinese example. With a perfect storm of circumstances around it, India has emerged as the world’s pharmacy, backed by FDA-compliant facilities, better cost efficiency (vis-à-vis China), and a vast and skilled talent pool. Slowly but steadily, India’s pharma sector is becoming more and more attractive for MNCs looking to script a China Plus One strategy that really works.       

Without a doubt, pharma players need pit stops beyond China

By end of 2022, foreign investors had pumped in $180 billion into China, and despite a nearly 6% year-on-year drop in such investments in the first five months of this year, the country still succeeded in attracting $84.35 billion. Leaning on relatively lower labor costs, a standard VAT rate (of 13%), and a tightly coupled China supply chain, the country has cemented its place as a hot favorite of Western business investors in the last more than four decades. Lower compliance requirements (versus those in the West) and a currency that is 15-20% undervalued against the dollar have helped Chinese suppliers boost exports.

Conveyor belt of competitively priced goods and services

As for US consumers, China continues to be a conveyor belt of competitively priced goods and services. China’s trade with the West and more particularly the US remains strong, and American businesses raked in around $200 billion from exports to China in 2021. On the flip side, China made nearly three times more from shipments to the US. US observers seem peeved not the least about a growing trade deficit with the Asian economic behemoth. There are also concerns in America’s upper echelons about China seeking to step up sway over sensitive worldwide supply chains and its potential access to advanced dual-purpose semiconductors and chip fabrication tools.

Chinese manufacturing certainly contracted during the pandemic in February 2020, and further weakening of the sector amid fresh infections in December 2022 brought home to Western MNCs the perils of overreliance on a single country source.  The “China Plus One” concept, interestingly coined way back in 2013, has since gained significant currency in Western business circles as a means of firewalling businesses from unplanned supply disruptions, unresolved trade issues, and geopolitical tensions linked to China.

Supply of inbound materials stands as a challenge

You lose your network of local suppliers when you relocate production. Rebuilding that inbound supply chain with new or existing vendors is definitely feasible, but it will take time. Prior to Covid, a significant electronics company relocated its factory from China, and as part of that relocation, the company’s primary suppliers agreed to move around the new production facility. The manufacturer was unable to localise its raw material supply as rapidly as anticipated after COVID struck since the movements had not been made. “It was bad luck to some extent and taught us the importance of having a local supply base in place before moving,” stated the logistics manager of the company. Due to the lockdowns in China during the peak of the COVID outbreak, smartphone assemblers experienced a two-month shutdown. Prior to the pandemic, domestic smartphone production had increased significantly, but manufacturers were still heavily dependent on Chinese suppliers.

India, the next attractive destination

Essentially, the China Plus One strategy for supply chain involves pivoting away from China, without disengaging from the country, and leaning toward the other Asian giant, India, to take advantage of the latter’s capability to deliver at scale in key sectors like pharma, besides IT/ITeS, and metals. (Other candidates vying for a share of the “China Plus One” pie include Vietnam, Thailand, Malaysia, and Indonesia). India’s $42 billion pharmaceutical sector is third largest manufacturer of medicines, globally, and accounts for a third of all pills consumed in the US.

As input cost inflations threaten to progressively erode the cost advantage of China’s manufacturing base, attractive investment sops, production-linked incentives, FDA-compliant facilities, and competitive wages are giving India an edge in the global pharma landscape. At current prices, it costs pharma MNCs a third lower to manufacture in India. Besides, the country’s pharma sector is busy energizing the domestic chemical ecosystem to cut back its dependence on China for key active pharmaceutical ingredients (APIs) by nearly a third. 

The Future of Supply Chain and China Plus One

The China Plus One strategy will play a pivotal role in shaping the landscape of where products are made. The shift is already happening, with many automotive and electronics companies expanding their supply chain and operations to India and Vietnam, as well as Mexico. This supply chain strategy aims to reduce global dependency on China, addressing the risk associated with concentrating manufacturing in a single country. Companies are entering a new phase of the strategy that focuses on a long-term presence in low-cost countries in Asia. This means that beyond the supply chain, many companies will be setting up local production and distribution teams in other countries to grow their global presence, reducing the reliance on China even further.

This shift is partially driven by trade tensions and COVID-19 disruptions, which have highlighted the vulnerabilities of a China-centric supply chain. Additionally, rising labor costs in China are prompting businesses to seek more cost-effective locations, also referred to as “plus one” locations. Countries like India and Vietnam offer not only lower labor costs but also a growing domestic market and improving geopolitical stability. Adopting a diversification strategy helps in risk mitigation by spreading out production across multiple regions, thereby reducing the impact of localized disruptions. This approach also involves outsourcing parts of the production process to take advantage of specialized capabilities and cost advantages in different regions.

However, moving operations out of China is not without its challenges. Companies must consider supplier reputation and the ability to maintain high standards of quality and reliability. Ensuring compliance management with local regulations in new markets is crucial, as is adapting to the Chinese political movements and the evolving regulatory environment. The end of China’s “Zero-Covid” policy may ease some of the COVID-19 disruptions, but businesses are still cautious about future uncertainties. As companies establish a presence in “plus one” locations, they must navigate the complex landscape of geopolitical stability, trade tensions, and rising labor costs. Ultimately, these shifts will likely lead to debates around geopolitical dynamics, intellectual property protection, and environmental sustainability. As more businesses implement the China Plus One strategy, the supply chain will evolve, offering companies numerous options to produce and distribute goods outside of China, thereby enhancing global resilience and operational flexibility.

Considering adopting a China Plus One strategy: Here are a few pros and cons

Pros

Risk Mitigation

Risk mitigation is a primary reason for considering the China Plus One strategy. Supply chain disruptions can arise from various factors such as natural disasters, political tensions, or global pandemics. Relying on a single country for your supply chain can halt your production process with any one of these disruptions. By establishing suppliers in multiple countries, China Plus One significantly reduces risk, creating a highly adaptable supply chain capable of withstanding unexpected challenges.

Better Compliance Management

Legislation like the Uyghur Forced Labor Prevention Act (UFLPA) introduced by the United States Congress aims to combat forced labor practices in parts of China. Companies violating these requirements, whether knowingly or unknowingly, may face product seizures at the border and damage their reputation among customers. To avoid such risks, diversifying your supply chain and sourcing components from alternate regions can be crucial, ensuring compliance and safeguarding critical parts of your supply chain from unreliable actors in China.

Market Access

Selecting “Plus One” destinations allows your company to tap into diverse markets, leveraging this strategically to your advantage. By diversifying your manufacturing or supply chain operations to different regions, you gain direct insights into consumer behavior, trends, and demands in various parts of the world, enabling a deeper understanding of your target audience.

Cost Savings

Rising labor costs in China are a significant driver behind the China Plus One strategy. While China was initially renowned for cost-effective labor and production, other countries now offer similar advantages. Adopting China Plus One enables your company to explore competitive labor costs, favorable exchange rates, and tax incentives in different countries, leading to substantial cost savings.

Technology and Expertise

Certain regions are renowned for their expertise in specific industries and technologies. Expanding manufacturing to these areas grants your company access to advanced technologies not readily available elsewhere, providing a competitive edge. Additionally, you can tap into specialized labor markets with individuals possessing expertise in these fields, enhancing your operational capabilities.

 Cons

Upfront Costs

Implementing a China Plus One strategy involves initial investments, embodying the saying, “sometimes you need to spend money to make money.” While this strategy can eventually lead to cost savings, it requires time and resources to identify new suppliers, ensure they meet regulatory and trade compliance standards, and understand the new risks and advantages associated with new locations.

Quality Control

Expanding your supply chain across multiple countries complicates quality control. Maintaining consistent product quality demands meticulous monitoring, testing, and compliance efforts. Failure to implement robust quality control measures across operations can lead to poor customer satisfaction and a tarnished brand reputation, necessitating additional resources to uphold standards throughout the supply chain.

Economic and Political Risks

Assessing the economic and political risks of “Plus One” countries is crucial. Factors such as currency fluctuations, labor strikes, regulatory changes, and geopolitical tensions must be considered. Staying ahead of shifting political landscapes and adapting to dynamic economic environments require additional resources and risk management strategies to prevent potential disruptions.

How your business can benefit from SpendEdge intelligence and solutions


How your business can benefit from SpendEdge intelligence and solutions

How SpendEdge can help you

Proliferation of chronic health conditions (e.g., cancer, diabetes, dementia) and elevated risk of pandemics is fueling growth in contract manufacturing spend by global pharmaceutical industry. Major pharma players are also betting big on post-China manufacturing locations, but businesses are scouting for partners who can put their money to work. At SpendEdge’s pharmaceutical excellence center, 80+ experts work closely with market participants of all sizes in around 60 countries to streamline their contract manufacturer selection process.

Our clients have successfully expanded their manufacturing footprint in promising yet daunting markets like India, Vietnam, Thailand, Malaysia, and Indonesia with significant competitive advantages and competencies. This is helping clients reduce risk of overreliance on the supply from China, improve compliance score, and mercilessly cut back the cost flab. In a span of two decades, we have clocked 1,000+ demanding pharma projects! Our practitioners apply thoroughly vetted market intelligence data to specific contract manufacturing contexts to help clients discover efficient service providers in various country markets. We deliver services across the continuum of market intelligence services, covering regulatory requirements, sustainable practices, as well as supplier discovery, selection, and continuous KPI management.

An American pharma enterprise savors the early fruits of a China Plus One strategy

Our client is a North America-headquartered pharma company with a significant dependence for dose manufacturing and packaging from vendors in eastern China. China is a key player when it comes to global API supplies, and this, along with lavish government incentives for pharmaceutical manufacturing and the famed China supply chain strategy, has attracted the client to Chinese shores nearly a decade ago. Affordable drug innovation was a big draw at that point with foreign drug manufacturers moving a diverse portfolio of R&D activities offshore to stay on the vanguard of innovation and breakthrough in drug development. Ever since, the client has improved its competitive edge a bit, besides benefiting from some cost efficiencies.

However, since the onset of the pandemic, there are a few disquieting questions about the continued feasibility of China as a single country source for drug development and production. For one, Covid lockdowns put the brakes on Chinese manufacturing, and domestic demand for medications moved the industry’s focus in that direction, leaving MNC pharma players scrambling for alternative sourcing destinations. At the same time, the cost of China-made drug ingredients jumped by more than 2x. Moreover, minimum wages in several of the country’s provinces are only about 4x lower than in the US.

Add to this input cost inflation and the country’s cost competitiveness story seems to be losing its sheen. Besides, with the US clamping punitive tariffs on China since 2018, and Beijing responding in like manner, pharma businesses know there are going to be cost implications if they continue to build out their manufacturing bases in China. The tight pharma talent pool in the country, an after-effect of the one-child policy, is also proving to be a disincentive for foreign drug industry recruiters. Moreover, China’s reported bid to increase its share of the global supply chain infrastructure might bring it into conflict with American interests, and as a US-domiciled business, our client is concerned that its supply networks might get embroiled in geopolitical tussles.

In early 2022, for the first time the client had a long and frank phone call with our experts about the potential of diversifying manufacturing away from China. In theory, overdependence on any one market certainly poses concentration risks for businesses, but only fact-based research can bear out the truth of that assumption. Our experts performed an in-depth assessment of the potential risks and limitations an exclusive China-centric sourcing policy is prone to. Furthermore, our teams looked over the sourcing best practices of peer groups to get an under-the-bonnet view of their sourcing markets with all their pros and cons. Our experts were able to give the client a measure of how various “China Plus One” opportunities (e.g., India, Vietnam, Thailand, Malaysia, and Indonesia) stack up against one another.

At the end of a month-long grueling study, our experts identified a short list of the top-three most attractive “China Plus One” sourcing destinations, further broken down by key considerations like supplier availability, capacity, quality, pricing, and political stability for each destination. As a next step, we assisted the client’s procurement team in identifying the top 10 suppliers in each location, further detailing their capacity, market credibility, pricing, as well as certifications and qualifications. At the moment, the client’s negotiation with tier-1 suppliers in a “China Plus One” market is in advanced stages. 

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Conclusion

China’s position as the world’s manufacturing powerhouse is being challenged by rising costs, geopolitical tensions, and strategic supply chain diversifications such as the China Plus One strategy. This approach, aimed at reducing dependence on China, is gaining traction as companies look to mitigate risks and explore cost-saving opportunities. India, among other countries, is emerging as a favorable alternative for pharmaceutical manufacturing due to its cost efficiency, compliance with international standards, and skilled workforce. As global supply chains continue to evolve, businesses are increasingly considering diverse manufacturing locations to enhance resilience, compliance, and cost-effectiveness.

Author’s Details

Ankur Rishi

Vice President, Sourcing and Procurement Intelligence

With more than 12 years of advisory experience, Ankur manages platform content and services within the sourcing and procurement vertical. Over the years, Ankur has provided consulting services to category leaders from chemicals, energy, and packaging industry, on varied topics, such as category strategy, spend analysis, commodity pricing, and clean-sheet analysis.

 

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Frequently asked questions

The China Plus One strategy is relevant now due to increasing labor costs in China, geopolitical tensions, trade conflicts, and disruptions caused by the COVID-19 pandemic. These factors have highlighted the risks of overreliance on a single country for manufacturing, prompting companies to diversify their supply chains to enhance resilience and reduce vulnerabilities.

The China Plus One strategy was not initiated by a single entity but has evolved over time as a collective response from global businesses seeking to mitigate risks associated with heavy dependence on China. The concept gained significant traction around 2013 as companies began to actively seek alternative manufacturing locations.

The beneficiaries of the China Plus One strategy include multinational companies that diversify their supply chains, countries like India, Vietnam, Thailand, Malaysia, and Indonesia that attract new investments, and consumers who benefit from more stable and cost-effective supply chains. Additionally, suppliers in these alternate locations also benefit from increased business opportunities.

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